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Promethazine with codeine syrup brands. and methadone are frequently used interchangeably among opioids. Although methamphetamine can be derived from either methadone or codeine, the potency of drugs varies, and methadone is typically considered less potent than codeine in the illicit market []. potency of hydrocodone may range from 100 to 500 mg/ml, and morphine from 100 to 500 mg/ml. Hydrocodone and methadone tend to be combined with other opioids, including codeine, to enhance their potency [ ]. Generic pharmacy drug list One study indicated that, compared to either codeine alone or codeine/acetaminophen alone, hydrocodone increases the potency of methadone by 7-fold and morphine 20-fold []. In a study conducted single clinic, hydrocodone (40 mg) was administered as a single daily oral injection for 14 consecutive days, and the opioid dose was escalated from 0.5 mg to 35 mg/kg/dose. The mean opioid dose within sample was 0.9 ± 0.3 mg/kg/d using a weight-based method []. In randomized, double-blind study, intravenous hydrocodone doses of 17 mg/kg/d hydrochloride were administered orally for 12 hours to healthy, normal subjects. The mean intravenous opioid dose was 0.7 ± 0.2 mg/kg/d